I recommend pre-washing your backing fabric to reduce shrinkage in your quilt and to remove any excess dyes in the fabric.
I just purchased a piece of flannel for the backing of a baby quilt, and it measured 63 5/8 x 43 1/2 before washing, and after washing & drying on low heat it measured 60 1/2 x 42. That's 3" lost through shrink on the length (parallel to the selvedges)... flannel would probably shrink more than regular quilting cotton, but that's not a given either, depending on the brand of fabric.